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Next oral administration of radiolabeled zafirlukast to volunteers, urinary excretion accounts for roughly 10% of the dose and the rest is excreted in feces. Zafirlukast will not be detected in urine.Zafirlukast is thoroughly hepatically metabolized by an enzyme referred to as CYP2C9. Zafirlukast inhibits the motion of CYP3A4, leading to drug-drug